By Navnit Shah,Harpreet Sandhu,Duk Soon Choi,Hitesh Chokshi,A. Waseem Malick
This quantity deals a complete advisor at the thought and perform of amorphous strong dispersions (ASD) for dealing with demanding situations linked to poorly soluble medications. In twenty-three inclusive chapters, the publication examines thermodynamics and kinetics of the amorphous kingdom and amorphous reliable dispersions, ASD applied sciences, excipients for stabilizing amorphous sturdy dispersions resembling polymers, and ASD production applied sciences, together with spray drying, sizzling soften extrusion, fluid mattress layering and solvent-controlled micro-precipitation expertise (MBP). every one know-how is illustrated via particular case stories. moreover, committed sections conceal analytical instruments and applied sciences for characterization of amorphous strong dispersions, the prediction of long term balance, and the advance of compatible dissolution tools and regulatory facets. The publication additionally highlights destiny applied sciences at the horizon, comparable to supercritical fluid processing, mesoporous silica, KinetiSol®, and using non-salt-forming natural acids and amino acids for the stabilization of amorphous systems.
Amorphous good Dispersions: conception and perform is a precious connection with pharmaceutical scientists attracted to constructing bioavailable and therapeutically potent formulations of poorly soluble molecules so one can enhance those applied sciences and improve higher medicinal drugs for the future.
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Extra resources for Amorphous Solid Dispersions: Theory and Practice (Advances in Delivery Science and Technology)
Amorphous Solid Dispersions: Theory and Practice (Advances in Delivery Science and Technology) by Navnit Shah,Harpreet Sandhu,Duk Soon Choi,Hitesh Chokshi,A. Waseem Malick