Download e-book for kindle: Analytical Method Development and Stability Studies of by Kishanta Kumar Pradhan,Ranganadha Rao K,P. Srinivasulu

By Kishanta Kumar Pradhan,Ranganadha Rao K,P. Srinivasulu

Master's Thesis from the 12 months 2011 within the topic medication - Pharmacology, grade: 8.0, , direction: B.Pharm.,M.Pharm, language: English, summary: A opposite part excessive functionality liquid chromatographic process (HPLC) has been constructed for the tactic improvement validation of Carvedilol in bulk and pharmaceutical formula through the use of YMC PACK professional 4.6 X a hundred and fifty mm (5µm Particle size). The cellular section was once Buffer: Acetonitrile: (70:30) and pH was once adjusted to two pumped at a circulation expense of one ml/min and the eluents have been monitored at 320nm. Linearity used to be received within the focus diversity of 10-90 μg/ml. The retention time of Carvedilol was once stumbled on to be 3.2 minute. the tactic was once confirmed for specificity, accuracy, precision, linearity, and restrict of detection, restrict of quantification, robustness and solubility balance. LOD and LOQ have been came across to be 0.001 μg/ml and 0.011μg/ml respectively. the strategy was once statistically established and RSD used to be chanced on to be lower than 2% indicating excessive measure of accuracy and precision of the proposed HPLC strategy. balance research file printed that the drug is weak for acidic, alkaline, oxidative, photolytic and UV degradation. The drug is good to thermal degradation. extra over the degradants have been good separated from its API. because of its simplicity, rapidness, excessive precision and accuracy, the proposed HPLC technique can be utilized for picking Carvedilol in bulk drug samples or in pharmaceutical dosage forms.

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Analytical Method Development and Stability Studies of Carvedilol by Kishanta Kumar Pradhan,Ranganadha Rao K,P. Srinivasulu


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